April 11, 2026 1:21 PM
Genetic variations linked to weight loss, side effects from GLP-1 drugs
Weight-loss responses to GLP-1 obesity drugs, and risks of side effects, may be linked to genetic variants, according to a study conducted by DNA-testing service 23AndMe. The study of nearly 28,000 23AndMe users who reported taking the weight-loss drugs found that a mutation in GLP1R, the gene for the protein targeted by GLP-1 drugs, is modestly but significantly associated with increased efficacy of the medications, researchers reported in Nature. People carrying one copy of that variant lost...