November 19, 2025 11:21 AM
Indian scientists help rewrite 50-year-old biological rule
Indian scientists, in collaboration with researchers from Rutgers University, have challenged a fundamental biological concept that has shaped textbook understanding of bacterial gene regulation for nearly five decades. Their findings could open new possibilities for developing antibiotics and studying bacterial evolution. For years, biology textbooks have described the “sigma cycle,” a model based primarily on Escherichia coli σ70, which suggested that sigma factors bind to RNA polymerase...