October 10, 2024 5:19 PM

Scientists discover key enzyme to overcome cancer drug resistance

Scientists from the Indian Association for the Cultivation of Science (IACS), Kolkata, have identified a new therapeutic target by activating a DNA repair enzyme called Tyrosyl-DNA phosphodiesterase 1 (TDP1). This discovery could pave the way for combination therapy, offering hope for patients who are resistant to existing cancer treatments. Current anticancer drugs like Camptothecin, Topotecan, and Irinotecan focus on inhibiting the enzyme Topoisomerase 1 (Top1), which is essential for DNA rep...